Investigating Causal Relations between Public Spending and Economic Growth in Europe

The link between economic growth and the size of the public sector has fuelled one of the most wide-ranging debates in economic literature and the empirical evidence is far from conclusive. With different techniques that encompass both country-to-country causality analysis with VAR models and standard and grouped panels, we study this relationship for a sample of 25 countries from the 1960s to the present. Our contribution is fundamentally methodological, overcoming several pitfalls of the previous literature, namely, endogeneity, dynamic effects and common patterns. The results do not support the fulfilment of the Wagner''s Law and a negative effect of public size on economic growth is highlighted. La relación entre tamaño del sector público y crecimiento económico ha dado lugar a una ingente literatura, tanto teórica como empírica. Sin embargo, la evidencia está muy lejos de ser concluyente. Este trabajo tiene por objeto investigar dicha relación para una muestra de 25 países europeos desde la década de 1960 hasta la actualidad. A tal efecto, se aplican diversas técnicas que comprenden el análisis de causalidad individual con modelos VAR y modelos de datos de panel, tanto tradicionales como de efectos agrupados. Nuestra contribución es esencialmente metodológica, puesto que permite superar algunos de los principales escollos de la literatura anterior: la endogeneidad, los efectos dinámicos y la omisión de patrones comunes. Los resultados obtenidos no sustentan la ley de Wagner y destacan, para la muestra seleccionada, la existencia de un efecto negativo del tamaño del sector público sobre el crecimiento económico

Business cycle patterns in European regions

The aim of this paper is threefold. First, we analyze the comovements of business cycles in European regions. Second, we date these business cycles and identify clusters of regions with similar business cycle behavior, using Finite Mixture Markov models. Third, we develop a new index to measure within-country homogeneity. We find that comovement among regions is, on average, quite low, although it increased during the convergence process prior to the euro cash and after the onset of the Great Recession. We identify five different groups of European regions. We also find heterogeneity in the size of border effects

Light-cone analysis of ungauged and topologically gauged BLG theories

We consider three-dimensional maximally superconformal Bagger-Lambert-Gustavsson (BLG) theory and its topologically gauged version (constructed recently in arXiv:0809.4478 [hep-th]) in the light-cone gauge. After eliminating the entire Chern-Simons gauge field, the ungauged BLG theory looks more conventional and, apart from the order of the interaction terms, resembles N=4 super-Yang-Mills theory in four dimensions. The light-cone superspace version of the BLG theory is given to quadratic and quartic order and some problems with constructing the sixth order interaction terms are discussed. In the topologically gauged case, we analyze the field equations related to the three Chern-Simons type terms of N=8 conformal supergravity and discuss some of the special features of this theory and its couplings to BLG.Comment: 22 pages; v2 some typos correcte

Super-Yang-Mills and M5-branes

We uplift 5-dimensional super-Yang-Mills theory to a 6-dimensional gauge theory with the help of a space-like constant vector $\eta^M$, whose norm determines the Yang-Mills coupling constant. After the localization of $\eta^M$ the 6D gauge theory acquires Lorentzian invariance as well as scale invariance. We discuss KK states, instantons and the flux quantization. The 6D theory admits extended solutions like 1/2 BPS `strings' and monopoles.Comment: 15 pages; minor changes, to appear in JHE

Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy

AIM: To evaluate the potential association of xeroderma pigmentosum group D (XPD) codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer. METHODS: We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage III (48%) and IV (20%) gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy. RESULTS: Statistical analysis showed that 75% (12 of 16) of relapse patients showed Lys /Lys genotype more frequently (P = 0.042). The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis (HR: 3.07, 95% CI: 1.07-8.78, P = 0.036) and Kaplan-Meir test (P = 0.027, log-rank test). CONCLUSION: XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients

Eliminating ambiguities for quantum corrections to strings moving in AdS4×CP3AdS_4\times \mathbb{CP}^3

We apply a physical principle, previously used to eliminate ambiguities in quantum corrections to the 2 dimensional kink, to the case of spinning strings moving in $AdS_4\times \mathbb{CP}^3$, thought of as another kind of two dimensional soliton. We find that this eliminates the ambiguities and selects the result compatible with AdS/CFT, providing a solid foundation for one of the previous calculations, which found agreement. The method can be applied to other classical string "solitons".Comment: 18 pages, latex; references added, comments added at end of section 4, a few words changed; footnote added on page 1

AdS_4/CFT_3 -- Squashed, Stretched and Warped

We use group theoretic methods to calculate the spectrum of short multiplets around the extremum of N=8 gauged supergravity potential which possesses N=2 supersymmetry and SU(3) global symmetry. Upon uplifting to M-theory, it describes a warped product of AdS_4 and a certain squashed and stretched 7-sphere. We find quantum numbers in agreement with those of the gauge invariant operators in the N=2 superconformal Chern-Simons theory recently proposed to be the dual of this M-theory background. This theory is obtained from the U(N)xU(N) theory through deforming the superpotential by a term quadratic in one of the superfields. To construct this model explicitly, one needs to employ monopole operators whose complete understanding is still lacking. However, for the U(2)xU(2) gauge theory we make a proposal for the form of the monopole operators which has a number of desired properties. In particular, this proposal implies enhanced symmetry of the U(2)xU(2) ABJM theory for k=1,2; it makes its similarity to and subtle difference from the BLG theory quite explicit.Comment: 32 pages, v2: references added, minor changes, v3: some clarifications, published versio

Dose-finding study and pharmacogenomic analysis of fixed-rate infusion of gemcitabine, irinotecan and bevacizumab in pretreated metastatic colorectal cancer patients

BACKGROUND: To determine the dose-limiting toxicity (DLT), maximum tolerated dose, recommended dose (RD) and preliminary evidence of activity of escalating doses of irinotecan (CPT-11) fixed-dose-rate infusional gemcitabine (FDR-GMB) and bevacizumab in pretreated metastatic colorectal cancer (mCRC) patients. Pharmacogenomic analysis was performed to investigate the association between VEGF single-nucleotide polymorphisms and clinical outcome. PATIENTS AND METHODS: A total of 89 mCRC patients were recruited in a two-step study design; 28 were included in the dose-finding study and 59 in the pharmacogenomic analysis. The FDR-GMB of 1000 mg m⁻², bevacizumab 5 mg kg⁻¹ and CPT-11 doses ranging from 100 to 160 mg m⁻² were explored. The VEGF protein serum levels were quantified by EIA. Allelic discrimination was performed to genotype polymorphisms in the VEGF gene. RESULTS: CPT-11 RD was 150 mg m⁻². Diarrhoea and neutropenia were the DLT. After a median follow-up of 42 months, the median time to progression (TTP) and overall survival were 5.2 and 19.9 months, respectively. VEGF levels were significantly correlated with VEGF-2578AA and VEGF-460CC genotypes, and a trend was observed with VEGF+405GG genotype. The presence of any of these genotypes correlated with a longer median TTP (8.8 vs 4.5 months, P=0.04). CONCLUSION: The triplet combination tested in this study is effective and well tolerated. A possible predictive role for VEGF gene polymorphisms and baseline VEGF circulating levels is suggested

Combining chemotherapy and targeted therapies in metastatic colorectal cancer

Colorectal cancer remains one of the major causes of cancer death worldwide. During the past years, the development of new effective treatment options has led to a considerable improvement in the outcome of this disease. The advent of agents such as capecitabine, irinotecan, oxaliplatin, cetuximab and bevacizumab has translated into median survival times in the range of 2 years. Intense efforts have focused on identifying novel agents targeting specific growth factor receptors, critical signal transduction pathways or mediators of angiogenesis. In addition, several clinical trials have suggested that some of these molecularly targeted drugs can be safely and effectively used in combination with conventional chemotherapy. In this article we review various treatment options combining cytotoxic and targeted therapies currently available for patients with metastatic colorectal cancer

Deformation of the ABJM Theory

In this paper we analyse the ABJM theory on deformed spacetime. We show that this theory reduces to a deformed super-Yang-Mills theory when one of the scalar superfields is given a non-vanishing vacuum expectation value. Our analyse is done in N=1 superspace formulism.Comment: 10 pages, 0 figures, accepted for publication in EP